Keith L Kirkwood Selected Research

Alveolar Bone Loss

1/2022	Inhibition of acid sphingomyelinase by imipramine abolishes the synergy between metabolic syndrome and periodontitis on alveolar bone loss.
4/2020	Acid sphingomyelinase deficiency exacerbates LPS-induced experimental periodontitis.
8/2019	Activation of vitamin D in the gingival epithelium and its role in gingival inflammation and alveolar bone loss.
1/2019	Functionalized nanoparticles containing MKP-1 agonists reduce periodontal bone loss.
1/2012	MAPK usage in periodontal disease progression.
3/2011	Silencing mitogen-activated protein kinase-activated protein kinase-2 arrests inflammatory bone loss.
10/2007	A p38 mitogen-activated protein kinase inhibitor arrests active alveolar bone loss in a rat periodontitis model.
3/2007	Actinobacillus actinomycetemcomitans lipopolysaccharide-mediated experimental bone loss model for aggressive periodontitis.
1/2007	A p38alpha selective mitogen-activated protein kinase inhibitor prevents periodontal bone loss.

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Keith L Kirkwood Research Topics

Disease

15	Periodontal Diseases (Periodontal Disease) 01/2022 - 10/2005
12	Inflammation (Inflammations) 01/2022 - 10/2008
10	Neoplasms (Cancer) 01/2021 - 10/2005
9	Alveolar Bone Loss 01/2022 - 01/2007
7	Periodontitis 01/2022 - 10/2007
5	Infections 08/2019 - 12/2003
5	Squamous Cell Carcinoma of Head and Neck 12/2014 - 05/2008
4	Bone Resorption 01/2015 - 05/2004
3	Neoplasm Metastasis (Metastasis) 01/2020 - 10/2005
3	Osteoarthritis 07/2012 - 10/2005
3	Rheumatoid Arthritis 07/2012 - 10/2005
2	Obesity 11/2021 - 10/2021
2	Carcinogenesis 01/2020 - 05/2008
2	Pathologic Processes 01/2020 - 10/2005
2	Head and Neck Neoplasms (Head and Neck Cancer) 05/2014 - 03/2013
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 01/2022
1	Insulin Resistance 01/2022
1	Niemann-Pick Diseases (Niemann Pick Disease) 04/2020
1	Stomatognathic Diseases (Dental Disease) 01/2018
1	Wounds and Injuries (Trauma) 01/2018
1	Body Weight (Weight, Body) 02/2012
1	Osteolysis 08/2009
1	Squamous Cell Carcinoma (Epidermoid Carcinoma) 05/2008
1	Aggressive Periodontitis (Periodontosis) 03/2007

Drug/Important Bio-Agent (IBA)

16	CytokinesIBA 01/2022 - 01/2007
8	LipopolysaccharidesIBA 01/2022 - 01/2007
7	p38 Mitogen-Activated Protein KinasesIBA 12/2014 - 01/2007
5	ChemokinesIBA 01/2021 - 07/2012
5	thiamine triphosphorate (TTP)IBA 05/2014 - 10/2008
4	Biological ProductsIBA 10/2021 - 01/2018
4	Mitogen-Activated Protein KinasesIBA 01/2020 - 01/2007
4	Proteins (Proteins, Gene)FDA Link 12/2014 - 05/2008
3	Interleukin-6 (Interleukin 6)IBA 03/2013 - 05/2004
3	TristetraprolinIBA 01/2012 - 10/2008
2	Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA 01/2022 - 04/2020
2	AcidsIBA 01/2022 - 04/2020
2	CeramidesIBA 01/2022 - 04/2020
2	RNA (Ribonucleic Acid)IBA 08/2019 - 01/2012
2	Messenger RNA (mRNA)IBA 12/2014 - 10/2008
2	Protein Kinases (Protein Kinase)IBA 08/2013 - 03/2011
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2012 - 06/2011
2	Biomarkers (Surrogate Marker)IBA 06/2011 - 05/2008
1	Tartrate-Resistant Acid PhosphataseIBA 01/2022
1	Palmitic Acid (Hexadecanoic Acid)IBA 01/2022
1	Imipramine (Janimine)FDA LinkGeneric 01/2022
1	Nonesterified Fatty Acids (NEFA)IBA 01/2022
1	CholesterolIBA 01/2022
1	Transcription Factors (Transcription Factor)IBA 01/2022
1	CarbohydratesIBA 01/2022
1	salicylhydroxamic acid (SHAM)IBA 11/2021
1	SphingomyelinsIBA 04/2020
1	SphingolipidsIBA 04/2020
1	Vitamin D FDA LinkGeneric 08/2019
1	hydroxide ionIBA 08/2019
1	Cholecalciferol (Vitamin D3)FDA Link 08/2019
1	Mitogen-Activated Protein Kinase PhosphatasesIBA 01/2019
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 12/2014
1	SB 203580IBA 12/2014
1	Type 2 Galanin ReceptorIBA 05/2014
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 05/2014
1	MitogensIBA 08/2013
1	LuciferasesIBA 02/2013
1	CurcuminIBA 02/2012
1	Small Interfering RNA (siRNA)IBA 01/2012
1	Complement System Proteins (Complement)IBA 11/2011
1	Protein Phosphatase 1IBA 11/2011
1	ImmunosorbentsIBA 06/2011
1	Prostaglandins EIBA 06/2011
1	Dinoprostone (PGE2)FDA Link 06/2011
1	EnzymesIBA 06/2011
1	transcription factor NF-AT c3IBA 08/2009
1	RANK LigandIBA 08/2009
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 10/2008
1	Matrix Metalloproteinases (MMPs)IBA 05/2008
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 05/2008
1	Matrix Metalloproteinase 13IBA 10/2005
1	Clindamycin (Cleocin)FDA LinkGeneric 12/2003
1	Penicillins (Penicillin)FDA Link 12/2003
1	Anti-Bacterial Agents (Antibiotics)IBA 12/2003
1	Azithromycin (Zithromax)FDA LinkGeneric 12/2003
1	Pharmaceutical PreparationsIBA 12/2003
1	MacrolidesIBA 12/2003

Therapy/Procedure

3	Therapeutics 01/2019 - 01/2018
1	Diet Therapy (Therapy, Diet) 08/2019
1	Subcutaneous Injections 12/2014
1	Reoperation 07/2012
1	Injections 10/2007